Clinical significance of Osteoprotegerin, Vitamin D, Obestatin and some biochemical variables in Kidney failure Patients

Chronic kidney disease (CKD) is described as an abnormalities of renal function, existing for a long period time. By reason the early grades can be experiences no symptoms, its premature identification strenuous. initial stage CRD cause various complications, such anemia, matabolyic disorders bone mineral. The study was done to assess effect chronic on Osteoprotegerin, 1,25 dihydroxyvitamin D, Obestatin levels and some biochemical parameters in patients not undertaken dialysis therapy. In this case-control fifty-five with Kidney failure fourty healthy people were examined. Circulating concentrations D estimated by ELIZA technique, serum urea, uric acid, total protein calciumu enzymatically using spectrophotometer.
 Serum concentration Obestatin, function markers group higher (328.3±41.68 pg/mL; 15.52±4.28pg/mL; 183.2±10.35 mg/dL; 8.88±0.54 6.57±0.22 mg/dL) respectively comparison control (172.6±55.48 11.64±3.26 33.45±1.08 0.95±0.03 4.35±0.22 respectively. Vitamin Total Calcium Proteins level lower(24.49±2.53 ng/mL; 8.06±0.18 6.49±0.12 g/dL) compared controls (57.11±12.39 10.15±0.23 6.82±0.10 current reveals that circulating Osteoprotegerin are remarkably linked existence failure, data identify high prevalence deficiency insufficiency moderate severe nephropathy.